Biostim with Sculptra and Radiesse

after before Biostim

Zen Dermatology offers the latest in bio rejuvenation and biostimulatory treatments to help you achieve a more naturally youthful and radiant appearance. One of the most exciting developments in the minimally invasive anti-aging and aesthetic field is the use of hyperdilute Radiesse and Sculptra Aesthetic to stimulate collagen production, reverse the signs and underlying symptoms of aging and enhance your natural beauty.

As we age, our skin and underlying tissues lose collagen and elastin, as well as structural support leading to an increase in wrinkles, sagging, loss of volume, fine lines, and a dull complexion. But with hyperdilute Radiesse and Sculptra Aesthetic, we can actively increase your body’s own collagen production and both prevent and reverse the signs of aging.

So, what exactly is hyperdilute Radiesse and Sculptra Aesthetic? Both are injectable treatments that contain tiny particles of calcium hydroxylapatite (in the case of Radiesse) or poly-L-lactic acid, a polymer of lactic acid (in the case of Sculptra). When injected in small quantities, these biocompatible and biodegradable particles stimulate your body to produce new collagen and elastin, leading to smoother, firmer, and more youthful-looking skin.

Biostim with Sculptra and Radiesse

Hyperdilute Radiesse and Sculptra Aesthetic are particularly effective because they are injected in very small amounts, spread out over a larger area to create a more natural-looking result. It’s like feeding miracle grow to your fibroblast cells which activates them to create more collagen and elastin. This technique helps to stimulate collagen production and natural re-volumization and smoothing without creating the telltale “overfilled” or “frozen” look that can sometimes occur with other injectable treatments.

The benefits of hyperdilute Radiesse and Sculptra are numerous. Not only do these natural biostimulators help to smooth out wrinkles and fine lines, but they also create a more lifted and contoured appearance, restore lost volume, and create a glowing, radiant complexion. 

Unlike traditional fillers, which simply add volume to the face, hyperdilute Radiesse and Sculptra Aesthetic work by stimulating your body’s own natural collagen production, which means that the results can last for months or even years. Whereas HA (Hyalurinic acid) fillers add volume that is not necessarily yours, the additional volume Biostimulators promote is entirely your own, creating the most natural rejuvenation available. 

Another way to look at the difference between HA fillers and Biostimulators including hyperdilute Radiesse and Sculptra Aesthetic is to think of it like renting vs owning. Volume created from the injection of HA fillers is temporary and rented, vs the volume and restoration created by biostimulators such as Sculptra Aesthetic and hyperdilute Radiesse occurs upon the stimulation of your body’s own natural collagen and elastin and its 100% you.

If you’re looking for a safe, effective, and natural way to enhance your natural beauty and achieve a more youthful appearance, then Biostimulation using hyperdilute Radiesse and/or Sculptra Aesthetic may be the perfect choice for you. 

Biostimulators can be combined with microneedling, radiofrequency skin tightening (Vivace, RF Microneedling as well as Thermismooth RF), IPL (Intense Pulsed Light), HA dermal fillers (such as Restylane Contour, Restylane Defyne, Restylane Kysse, Restylane Lyft, Restylane Refyne, Restylane Silk, Restylane L, Juvederm Ultra XC, Juvederm Ultra Plus, Juvederm Volbella XC, Juvederm Vollure XC, Juvederm Voluma XC), wrinkle relaxers (such as Botox, Jeuveau, Dysport, Xeomin and Daxify), or some of our laser resurfacing services such as Fotona 4D, Fraxel Dual, Clear + Brilliant, Erbium Fractional ablative and non ablative modalities and CO2 to give you full transformation and optimal results.

Contact us today to learn more about these innovative treatments and how they can help you look and feel your best.

Face: Biostimulators for Natural Rejuvenation, Preventative and Anti-Aging

Placed Deeply:

  • Provides enhanced structural support to overlying tissues

  • Restores volume to hollow or sunken areas

  • Reduces tissue sagging

  • Improves the appearance of deeper lines/wrinkles

  • Promotes natural appearing re-volumization 

Placed Superficially:

  • Improves skin texture and tone (also known as skin conditioning)

  • Increases radiance for glowing skin (“Sculptra Glow”)

  • Softens fine lines and wrinkles

  • Improves the appearance of acne scars (paired with subcision)

  • Improves appearance of crepey skin

  • Enhances natural collagen and elastin stores to both slow and reverse the signs of aging

Neck: Biostimulators for a Tighter and More Youthful Appearing Neck


  • Reduces crepey or paper like skin

  • Improves skin turgor and elasticity

  • Tightens loose skin

  • Reduces the appearance of horizontal lines

Décolleté: Biostimulators for a More Youthful, Wrinkle Free Chest

  • Improves skin turgor and elasticity

  • Tightens loose skin

  • Smooths out wrinkles and creases (including those sleep wrinkles in the middle)


  • Reduces the appearance of thin, crepey skin
  • Restores volume to hollow areas
  • Softens fine lines and wrinkles

Arms: Biostimulators for Tighter Less Crepey Arm Skin

  • Reduces the appearance of crepey skin

  • Tightens loose skin

  • Improves and thickens thin skin

  • Softens fine lines and wrinkles

Buttocks: Biostimulators for a Natural BBL or Booty / Butt Lift and Cellulite Reduction

  • Restores and improves volume

  • Enhances the shape and contour of the buttocks

  • Reduces the appearance of cellulite

Preparing For Your Treatment

Biostimulator Pre-Treatment Instructions:

It is important to note that these instructions may vary depending on the specific treatment and the provider’s recommendations. Be sure to follow any instructions provided by your provider for the best possible results. If you have any concerns or questions before or after the treatment, don’t hesitate to contact Zen Dermatology.

Biostimulator Post-Treatment Instructions:


Here are some frequently asked questions about biostim and biorejuvenation for hyperdilute Radiesse and Sculptra:

Biorejuvenation is a non-surgical cosmetic treatment that uses Hyperdilute Radiesse or Sculptra Aesthetic to stimulate collagen production and improve the overall appearance (volume loss, fine lines, wrinkles, crepey, loose or sagging, hallows, cellulite) of the skin.

Biostim and biorejuvenation work by injecting small amounts of hyperdilute Radiesse or Sculptra into specific layers of the skin. These injections stimulate the body’s natural type I and III collagen production, which helps to restore volume and improve skin texture and tone.

The results of biostim and biorejuvenation can vary, but generally last greater than 18-24 months, often longer.

The number of treatments needed depends on the individual and their specific goals. Typically, patients receive 2-3 treatments spaced about 8 weeks apart initially to achieve the desired transformative results. Patients will then return typically for a single maintenance treatment annually.

After treatment, patients may experience some swelling, redness, tenderness or bruising at or below the level of the injection site. These side effects typically subside within a few days. Patients can usually return to their normal activities immediately after treatment. It is important to avoid excessive sun exposure and to use sunscreen to protect the skin.


Are You Ready To Schedule Your Unique Journey?

Schedule Your Consultation Today.

RAJA SIVAMANI-Dermatology-CA-Zen Dermatology



I am a native of the San Francisco Bay Area and a board certified Dermatologist. My expertise centers on general dermatology including medical, surgical, and cosmetic services. With training in bioengineering, Allopathic and Ayurvedic medicine, I merge modern research and science with a personalized approach to each patient. My training in Ayurvedic medicine lets me bring in a more humanistic approach to my patient care, science, and research.

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